US’s technology firms Oracle and AMD have announced a major expansion of their long-standing, multi-generation collaboration to help customers significantly scale their AI capabilities and initiatives.
Building on years of co-innovation, Oracle Cloud Infrastructure (OCI) will be a launch partner for the first publicly available AI supercluster powered by AMD InstinctTM MI450 Series GPUs — with an initial deployment of 50,000 GPUs starting in calendar third quarter 2026 and expanding in 2027 and beyond, the duo said in a statement on Wednesday.
This announcement builds upon the joint work of Oracle and AMD to deliver AMD Instinct GPU platforms on OCI to end customers, beginning with the launch of AMD Instinct MI300X powered shapes in 2024 and extending to the general availability of OCI Compute with AMD Instinct MI355X GPUs.
These will be available in the zettascale OCI Supercluster. Demand for large-scale AI capacity is accelerating as next-generation AI models outgrow the limits of current AI clusters.
To train and run these workloads, customers need flexible, open compute solutions engineered for extreme scale and efficiency.
OCI’s planned new AI superclusters will be powered by the AMD “Helios” rack design, which includes AMD Instinct MI450 Series GPUs, next- generation AMD EPYCTM CPUs codenamed “Venice,” and next-generation AMD PensandoTM advanced networking codenamed “Vulcano”.
This vertically-optimized, rack-scale architecture is designed to deliver maximum performance, scalability, and energy efficiency for large-scale AI training and inference.
“Our customers are building some of the world’s most ambitious AI applications, and that requires robust, scalable, and high-performance infrastructure,” said Mahesh Thiagarajan, executive vice president, Oracle Cloud Infrastructure.
“By bringing together the latest AMD processor innovations with OCI’s secure, flexible platform and advanced networking powered by Oracle Acceleron, customers can push the boundaries with confidence,
“Through our decade-long collaboration with AMD—from EPYC to AMD Instinct accelerators—we’re continuing to deliver the best price-performance, open, secure, and scalable cloud foundation in partnership with AMD to meet customer needs for this next era of AI,” he added.
Forrest Norrod, executive vice president and general manager, Data Center Solutions Business Group, AMD, said AMD and Oracle continue to set the pace for AI innovation in the cloud.
“With our AMD Instinct GPUs, EPYC CPUs, and advanced AMD Pensando networking, Oracle customers gain powerful new capabilities for training, fine-tuning, and deploying the next generation of AI,
“Together, AMD and Oracle are accelerating AI with open, optimized, and secure systems built for massive AI data centers,” he added.
It is noted that AMD Instinct MI450 Series GPU-powered shapes are designed to deliver high-performance, flexible cloud deployment options and provide extensive open-source support.
This provides the ideal foundation for customers running today’s most advanced language models, generative AI, and high-performance computing workloads.
With AMD Instinct MI450 Series GPUs on OCI, customers will be able to benefit from breakthrough compute and memory, AMD optimized “Helios” rack design, powerful head node, DPU-accelerated converged networking, scale-out networking for AI, innovative UALink and UALoE fabric, open-source AMD ROCmTM software stack, advanced partitioning and virtualization.
To give customers that build, train, and inference AI at scale more choice, OCI also announced the general availability of OCI Compute with AMD Instinct MI355X GPUs.
These will be available in the zettascale OCI Supercluster that can scale to 131,072 GPUs.

