Engine Biosciences, a Singapore-based company leveraging machine learning and high-throughput biology to discover and develop precision oncology medicines, has on Wednesday announced the completion of a $27 million Series A extension.

The financing was led by Polaris Partners, with participation from both new and existing investors, bringing the total funds raised since inception to $86 million, Engine Biosciences said in a statement.

According to the statement, additional participating investors include existing investors ClavystBio (a life sciences venture investor set up by Temasek), Invus, and Singapore-based global investor EDBI, as well as new investors Coronet Ventures (a Singapore-based investment entity of Cedars Sinai Intellectual Property Company) and SEEDS Capital (investment arm of Enterprise Singapore).

In conjunction with the financing, Wen Qi Ho Ph.D., Therapeutics Lead at ClavystBio, joined Engine Biosciences’ Board of Directors.

With the additional funds secured, Engine Biosciences said it will further advance its biomarker and target discoveries toward the clinic through internal development, collaborations, and partnerships

Engine Biosciences is a venture-backed Singapore- and Silicon Valley-based company discovering and developing impactful precision medicines by deciphering complex biology with integrated computation and experimentation, with particular depth in oncology gained over several years of substantial investment and focus.

The firm is advancing its pipeline of oncology therapeutics towards the clinic internally and with collaborators, and in other disease areas through partnerships.

The firm’s precision medicine research and development (R&D) platform deciphers biological networks and pinpoints key genetic interactions driving diseases, overcoming challenges presented by biological complexity.

These insights reveal targets and therapeutics to be used in biomarker-defined patient populations, allowing for more rapid identification of effective precision medicines.

In oncology, Engine Biosciences leverages the validated principle of synthetic lethality and is focused on the clinical translation of therapeutics and biomarkers across solid tumors, including ovarian, colorectal, liver, lung and prostate cancers.

“Our findings support Engine Biosciences mission to deliver clinical impact through directing the right drug for the right target to the right patient,

“We appreciate the confidence of both existing and new investors demonstrated through this financing, as we continue steadfast in our goals to drive clinical translation of our insights, internally and with partners,” said Jeffrey Lu, Engine Biosciences’ Co-Founder and Chief Executive Officer.

Engine Biosciences has revealed over thirty previously unidentified precision medicine opportunities with validation data, anchoring its pipeline and feeding partnerships.

Its internal drug discovery biology and chemistry teams have progressed multiple programs significantly from initial identification.

Among its oncology pipeline is ENB-812, which Engine Biosciences has overseen from independently discovering PKMYT1 as a synthetic lethal target with novel biomarkers in 2019, generating robust preclinical proof-of-concept across many tumor types and animal models, observing supportive clinical data, and advancing lead identification and optimization.

In addition to high-value targets and drug candidates, Engine identified new patient selection biomarkers for several distinct classes of targeted therapies.

Engine Biosciences’ biomarkers have been validated to sensitize tumors by 100 times to specific clinical-stage investigational drugs.

These biomarkers present near-term potential to enhance clinical outcomes, increase commercial potential, and improve drug development economics.

“We have witnessed first-hand Engine Biosciences’ considerable progress since our initial investment, advancing its technologies towards compelling precision medicines positioned for translation,

“We are excited to lead this strong investor syndicate in support of Engine Biosciences’ pursuit of clinical value creation through development of its therapeutics and biomarkers and partnerships,” said Amy Schulman, Managing Partner of Polaris Partners.

Benefiting from several years of research and development in its Singapore and Silicon Valley sites and foundational science from MIT, UCSF, UCSD, and Mayo Clinic, Engine Biosciences’ proprietary platforms, NetMAPPR (machine learning-enabled network biology) and CombiGEM (combinatorial genetics experimentation), are engineered for drug hunters and clinical developers to discover and optimise precision medicines.

In addition to high-value targets with associated biomarker-defined patient populations, Engine Biosciences’ extensive biology knowledge and datasets provide insights on desirable target product profile characteristics, guiding design and optimisation of first-in-class and best-in-class therapeutics.

“We are excited about supporting Engine’s growth as a global biotech company, with a strong syndicate of life sciences investors,

“This is consistent with our mission to translate breakthrough research into clinical impact, and build ventures in Singapore with access to talent, data and clinical opportunities internationally,” said Wen Qi Ho, Ph.D., Therapeutics Lead, ClavystBio.

It is noted that Engine Biosciences’ programs and platform are underpinned by an extensive patent portfolio.

“Precision medicine holds the key to the next wave of groundbreaking treatments, a belief that ties Coronet Ventures closely with Engine Biosciences mission,

“Investing in Engine Biosciences reflects our commitments to bringing research breakthroughs to clinical fruition, and anchoring ventures in Singapore that are primed for global success,” said Nirdesh Gupta, Ph.D., Chief Executive Officer of Coronet Ventures.

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